Liverpool goalkeeper Alisson Becker and midfielder Naby Keita are both still a few weeks away from fitness ahead of the visit of Arsenal.
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Alisson is off his crutches after a calf injury but will not be ready until after the international break. Keita is also looking at further time on the sidelines as he recovers from a muscle strain.
Mesut Ozil could make his first appearance of the season for Arsenal. The Gunners head to Anfield with Ozil available following illness, while midfielder Granit Xhaka is also in contention to return after missing the win over Burnley with bruising to his back.
Champions League winners against Europa League champs - the UEFA Super Cup has become the traditional curtain raiser for European competitions. This year's is a first - an all-English affair, with Liverpool taking on Chelsea. Which Premier League side will earn the bragging rights in Istanbul? You watch all the action no matter where you are in the world by following our Liverpool vs Chelsea UEFA Super Cup live stream guide below.
Club-record signing Nicolas Pepe is pushing to make his full debut following two substitute appearances but Konstantinos Mavropanos and Kieran Tierney (both groin) and Hector Bellerin and Rob Holding (both knee) are absent.
Tonight's match highlights something of a sea change in European football, with the balance of power perhaps slipping away from La Liga - no Spanish team will contest the Super Cup for only the second time since 2008 (Atletico Madrid are the reigning champions after beating Real in Tallinn last season).
This encounter brings together two teams from the same nation who have played each other an unusually frequent number of times on the European stage, with the Wednesday's Super Cup showdown the 11th meeting in UEFA competitions since 2005. Liverpool have notched up two wins in that time, while Chelsea edge it with three wins, the remaining five games having been stalemates.